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KMID : 0545120010110020350
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Journal of Microbiology and Biotechnology
2001 Volume.11 No. 2 p.350 ~ p.353
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Antibacterial Compound against Pasturella multocida and Actinobacillus pleuropneumoniae Causing Porcine Pneumonia
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LYOO, YOUNGSOO
PARK, DONGKI/LEE, SANGMOK/CHOI, YIDON/JUNG, JIHYUN/JUN, TAEIL/AHN, HONGSUK
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Abstract
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Porcine pneumonia is caused by Pasturella multocida and Actinobacillus pleuropneumoniae. To identify a potent drug for antipneumonia therapy, several herbal compounds showing antibacterial effects were screened, and it was found that a methanol extract of Coptidis rhizoma root stem exhibited activity against both pneumonia-causing bacteria. Using an activity-guided fragmentation procedure, an isoquinoline alkaloid was isolated which would be responsible for the antibacterial activities against P. multocida and A. pleuropneumoniae.
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